Data

All DO-HEALTH participants were extensively assessed and characterized at baseline and during the 3 year follow-up.

The table below shows all procedures, assessments, questionnaires performed at the different timepoints. The table can be searched and sorted. If available, the eCRF form/questionnaire itself can be downloaded by clicking on the PDF-icon*. A short legend can be found at the bottom of the table.

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Assessment type		Procedure, Assessment	Baseline on-site	Month 3,9,15, 21,27,33 ph call	Month 6,18,30 ph call	Month 12,24 on-site	Month 36 on-site
Biomarker		25(OH)D	X			X	X
Questionnaire		EQ5D-3L	X		X	X	X
Questionnaire		Diet assessment by Food Frequency Questionnaire	X				X
Questionnaire		QuickDASH	X			X	X
Biomarker		AA (PUFA)	X			X	X
		Adherence/Pill count##				X	X
		Adverse events		X	X	X	X
Biomarker		albumin	X			X	X
Biomarker		alkaline phosphatase	X			X	X
Biomarker		ALT	X			X	X
Biomarker		AST	X			X	X
Biomarker		bilirubin	X			X	X
Biomarker		Blood cell count	X
examination		Blood pressure	X			X	X
DXA		Body composition and fat mass†	X			X	X
DXA		Bone mineral density in the spine and hip†	X			X	X
Biomarker		calcium	X			X	X
Biomarker		CD3**	X			X	X
Biomarker		CD4**	X			X	X
Biomarker		CD25**	X			X	X
Biomarker		CD127**	X			X	X
Biomarker		chloride	X			X	X
Biomarker		cholesterol	X			X	X
Biomarker		CK	X			X	X
anamnestic		Co-Medication & Non-Medication Procedures	X	X	X	X	X
anamnestic		Comorbidities	X			X	X
Biomarker		cortisol	X			X	X
Biomarker		creatinine	X			X	X
Biomarker		CRP	X			X	X
anamnestic		Demographic information	X
examination		dental impression*	X			X
Biomarker		DHA (PUFA)	X			X	X
Biomarker		DPA (PUFA)	X			X	X
Biomarker		EPA (PUFA)	X			X	X
Questionnaire		Fall	X	X	X	X	X
anamnestic		Fall history	X
Biomarker		fasting glucose	X			X	X
Biomarker		ferritin	X			X	X
Biomarker		folic acid	X			X	X
Questionnaire, examination, x-ray		Fracture healing of incident fractures++
anamnestic		Fracture history	X
Questionnaire, DXA†		Fractures (non-vertebral, vertebral and hip)		X	X	X	X
Biomarker		fT3	X			X	X
Biomarker		fT4	X			X	X
GAITRite® Platinum		Gait analyses and dual task assessment‡	X			X	X
Questionnaire		GDS (excerpt)	X			X	X
Questionnaire		GOHAI	X			X	X
Martin Vigorimeter		Grip strength	X			X	X
Biomarker		HDL-cholesterol	X			X	X
examination		Height and weigth	X			X	X
Biomarker		homocysteine	X			X	X
Questionnaire		HOOS	X			X	X
		Hospital admissions		X	X	X	X
Biomarker		IL-6	X			X	X
Biomarker		IL-10**	X			X	X
Biomarker		IL-17**	X			X	X
Biomarker		IL-22**	X			X	X
		Implant infections after total hip or knee replacement		X	X	X	X
		Incident cancer		X	X	X	X
		Incident nephrolithiasis				X	X
		Incident symptomatic osteoarthritis (knee, hip, and hand)	X			X	X
Questionnaire		Infection	X	X	X	X	X
Biomarker		insulin	X			X	X
Biomarker		intact PTH	X			X	X
Questionnaire		Joint map	X			X	X
Questionnaire		KOOS	X			X	X
Biomarker		magnesium	X			X	X
		Major cardiovascular events		X	X	X	X
Questionnaire		Mc Gill pain map (modified version)	X			X	X
Questionnaire		MMSE	X
Questionnaire		MoCA (Montreal Cognitive Assessment)	X			X	X
		Mortality		X	X	X	X
DXA		Muscle mass in the upper and lower extremities (DXA)†	X			X	X
Biomarker		myostatin	X			X	X
Questionnaire		NHS, excerpt	X			X	X
Biomarker		NT-proBNP	X			X	X
		Nursing home admissions		X	X	X	X
Biomarker		P1NP	X			X	X
Biomarker		phosphate	X			X	X
		Physical activity	X			X	X
		Physical examination	X			X	X
Biomarker		potassium	X			X	X
Questionnaire		PROMIS-HAQ	X			X	X
Questionnaire		ROME III	X			X	X
Questionnaire		Sangha’s instrument	X			X	X
Biomarker		sclerostin	X			X	X
		Self-reported adherence to study treatments and exercise program		X	X	X	X
Questionnaire		SHARE-FI	X			X	X
examination		Short Physical Performance Battery	X			X	X
Biomarker		sodium	X			X	X
Questionnaire		Subjective cognitive decline (Subjective memory complains)**					X
		Symptomatic osteoarthritis (severity of knee pain, knee buckling, total number of joints with pain, and NSAID use)	X			X	X
Biomarker		TNF-α**	X			X	X
examination		Tooth count	X			X	X
Biomarker		total protein	X			X	X
Biomarker		transferrin	X			X	X
Biomarker		triglycerides	X			X	X
Biomarker		Troponin-T	X			X	X
Biomarker		TSH	X			X	X
Biomarker		urea	X			X	X
Biomarker		uric acid	X			X	X
Biomarker		urinary calcium/creatinine ratio (second spot urine)	X			X	X
Biomarker		vitamin B12	X			X	X
Biomarker		β-crosslaps	X			X	X
Biomarker		γ-GT	X			X	X
Questionnaire		KneeBuckling	X			X	X
Questionnaire		ParticipantSatisfaction				X	X
Questionnaire		SunlightExposure	X			X	X

on-site = clinical on-site visit; ph call = phone call visit
* 100 participants at site Zürich at baseline and 12 month visit only
** Assessed in 802 participants at two study centers Zurich and Basel
† Measurement taken in 1502 participants at four study centers equipped with iDXA machines.
‡ Measurement taken in 250 seniors recruited at Basel University Hospital.
##Pill count also performed outside clinical visits when required.
++ assessed only in individuals with incident major osteoporotic fractures at the arm (shoulder, humerus, forearm) and leg (hip, femur, ankle): PROMIS-HAQ at 6, 12, 18 weeks after the fracture; SPPB and grip strength at 12, 24 and 36 months; independent/external x-ray at 6-8 weeks and 12 to 14 weeks after the fracture, if available